Contraindicated in patients with known or suspected gastrointestinal obstruction, which includes paralytic ileus; may possibly cause spasm of sphincter of Oddi; opioids may well cause boosts in serum amylase; keep an eye on patients with biliary tract condition, which includes acute pancreatitis, for worsening symptoms
Monitor Carefully (one)enasidenib will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
berotralstat will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Observe or titrate substrate dose when berotralstat is coadministered with slender therapeutic index drugs which can be CYP3A substrates.
If coadministration of CYP3A4 inhibitors with fentanyl is necessary, check patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose changes till stable drug effects are reached
somatrogon will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Repotrectinib is a CYP3A4 inducer. Stay away from coadministration with CYP3A substrates where minimum concentration changes can cause decreased efficacy, Except if otherwise proposed their prescribing information.
buprenorphine transdermal and fentanyl both improve sedation. Avoid or Use Alternate Drug. Limit use to patients for whom substitute treatment options are inadequate
Life-threatening respiratory depression is much more likely to come about in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance as compared to younger, healthier patients
If not able to prevent coadministration of belzutifan with sensitive CYP3A4 substrates, consider expanding the delicate CYP3A4 substrate dose in accordance with its prescribing information.
After stopping a CYP3A4 inducer, as being the effects of your inducer decline, the fentanyl plasma concentration will raise which could boost or prolong each the therapeutic and adverse effects.
Right fentanyl vs heroin chemical structure before taking or using fentanyl, you can expect to normally get started on the very low dose of another type of opioid, such as morphine. This will likely be amplified little by little until your pain is effectively controlled.
glycerol phenylbutyrate will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Glycerol phenylbutyrate is really a weak inducer of CYP3A4. Observe for lessened efficacy of CYP3A4 substrates that have a narrow therapeutic index.
fentanyl, cyproheptadine. Both will increase toxicity of your other by pharmacodynamic synergism. Modify Therapy/Check Carefully. Coadministration of fentanyl with anticholinergics may perhaps improve risk for urinary retention and/or intense constipation, which may result in paralytic ileus.
Keep away from or substitute another drug for these medications when attainable. Appraise for loss of therapeutic effect if medication should be coadministered. Change dose according to prescribing information if essential.